Selective Cyclooxygenase-2 Inhibition Impairs Glomerular Capillary Healing in Experimental Glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis.
Selective cyclooxygenase-2 (COX-2) inhibitors have anti-inflammatory activity and reduce proteinuria in experimental membranous glomerulonephritis. Antiangiogenic properties of COX-2 inhibitors were recently reported. Whether these properties are relevant to the glomerular healing process in inflammatory glomerular diseases was investigated. For evaluation of the effects of selective COX-2 inhi...
متن کاملGlomerular damage in experimental proliferative glomerulonephritis under glomerular capillary hypertension.
BACKGROUND/AIMS Immunologically and hemodynamically mediated the destruction of glomerular architecture is thought to be the major causes of end-stage renal failure. The purpose of this study is to evaluate the effect of glomerular hypertension on glomerular injury and the progression of glomerular sclerosis after Thy-1 nephritis was induced. METHOD Thy-1 nephritis was induced in the stroke-p...
متن کاملSelective Cyclooxygenase-2 Inhibition Protects Against Myocardial Damage in Experimental Acute Ischemia
BACKGROUND Acute myocardial infarction is associated with tissue inflammation. Early coronary reperfusion clearly improves the outcome but may help propagate the inflammatory response and enhance tissue damage. Cyclooxygenase-2 is an enzyme that catalyzes the initial step in the formation of inflammatory prostaglandins from arachidonic acid. Cyclooxygenase-2 levels are increased when ischemic c...
متن کاملSystemic overexpression of hVEGF-165 in rat liver impairs glomerular healing in experimental mesangioproliferative nephritis
Vascular endothelial growth factor (VEGF) regulates vascular permeability and endothelial cell proliferation. In the rat anti-Thy1.1 mesangioproliferative nephritis inhibition of VEGF165 impairs glomerular endothelial repair. We now studied the effects of systemic overexpression of VEGF165 during glomerular endothelial damage in this model. Hepatic gene transfer was performed by tail vein injec...
متن کاملSelective cyclooxygenase-2 inhibition by nimesulide in man.
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation. Selective inhibition of Cox-2 is desirable as this may avoid the gastropathy and platelet inhibition seen with nonselective agents. Moreover, these agents will allow us to examine the relative contribution of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2002
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v1351261